Joao Goncalves
Associate Professor at Faculdade Farmacia Lisboa
- Location
- Portugal
- Industry
- Indústria farmacêutica
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Visão geral de Joao Goncalves
- Atual
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- Associate Professor na Faculdade Farmacia Lisboa
- Anterior
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- Assistant Professor na Faculdade de Farmácia Universidade Lisboa
- Research Fellow na The Scripps Research Institute
- Product Manager na Merck Sharp & Dohme
- Product Manager na Servier
- Research Fellow na Dana-Farber Cancer Institute
- Formação acadêmica
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- Universidade de Lisboa
- Recomendações
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1 pessoa recomendou Joao
- Conexões
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500+ conexões
- Sites
Resumo de Joao Goncalves
I am interested on biomolecular and biopharmaceutical engineering aiming the investigation, analysis and integration of genomic and proteomic data towards the design of therapeutic proteins. This will lead us to guide protein engineering through molecular medicine and bio-nanotechnology in a mid- to long-term timeframe. At the center of our biopharmaceutical development we aim at rational antibody engineering as our approach to validate our theoretical concepts. We consider the use of intracellular and extracellular small-domain antibodies to be exemplary in our rational protein engineering strategies. We have applied our stability engineering strategies to the construction of hyper-stable and effective small antibodies. We want to be able to use our hyperstable frameworks for the construction of small domain antibodies in a number of examples, ranging from HIV to cancer and in model domains to a designed catalytic intrabody.
My interest in protein therapeutics may stem the discovery and development of new leads for biopharmaceuticals in the area of infectious diseases, cancer and neurological problems. The focus on the discovery and development of a new class of therapeutic antibodies and efficient display technologies may allow the rapid identification of binding proteins with high affinity and specificity. The domain antibodies combine the advantages of conventional antibodies with the benefits of small-molecule drugs. In addition , we plan to adapt our antibody domain platform to other areas as inhibition of extracellular enzymes and cell surface receptors.
In addition to innovative biopharmaceuticals, quality and efficacy issues of protein therapeutics is a major focus of our scientific and technical approaches. We aim aim to develop integrative methods to assess biosimilar and biosuperior proteins. In this case, mechanisms of protein immunogenicity and factors that alter protein effectiveness are driving our attention.
Especializações
Consultant of biopharmaceutical companies with interests on protein therapeutics
Member of Evaluation Group of Veterinarian Medicines
Member of Portuguese Pharmacopeia Commission
Experiência de Joao Goncalves
Associate Professor
Faculdade Farmacia Lisboa
Educational Institution; 51-200 employees; Pesquisa industry
October 2006 – Present (6 years 9 months)
Assistant Professor
Faculdade de Farmácia Universidade Lisboa
Educational Institution; 51-200 employees; Pesquisa industry
January 2001 – September 2006 (5 years 9 months)
Research Fellow
The Scripps Research Institute
Nonprofit; 1001-5000 employees; Pesquisa industry
January 1999 – December 2000 (2 years)
Product Manager
Merck Sharp & Dohme
Public Company; 10,001+ employees; MRK; Indústria farmacêutica industry
January 1997 – December 1998 (2 years)
Product Manager
Servier
Privately Held; 10,001+ employees; Indústria farmacêutica industry
September 1995 – December 1996 (1 year 4 months)
Research Fellow
Dana-Farber Cancer Institute
Nonprofit; 1001-5000 employees; Atendimento médico e hospitalar industry
January 1990 – August 1995 (5 years 8 months) Boston
Competências e especialidades de Joao Goncalves
Formação acadêmica de Joao Goncalves
Universidade de Lisboa
PhD, Virology
Informações adicionais de Joao Goncalves
- Sites:
- Interesses:
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Consultant of biopharmaceutical companies with interests on antibody therapeutics
- Grupos e associações:
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